Genomic & Biopharma News

Scientists identify unique subtype of eczema linked to food allergy
Children with both conditions have abnormal skin near eczema lesions, NIH-funded research finds
National Institutes of Health, 2019-02-21 00:15:00

Ras and exosome signaling
Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited clinical utility. There have been attempts to develop and deliver mutant K-Ras silencing RNAs either ...
Exosome RNA Research & Industry News, 2019-02-20 22:27:34

New pathway for cell communication discovered
Small lipid vesicles known as extracellular vesicles are of great interest to cell scientists since it has been discovered that they mediate intercellular communication. Now, Professor Tom Carter’s...
Exosome RNA Research & Industry News, 2019-02-20 22:19:16

Single-cell RNA-seq denoising using a deep count autoencoder
Single-cell RNA sequencing (scRNA-seq) has enabled researchers to study gene expression at a cellular resolution. However, noise due to amplification and dropout may obstruct analyses, so scalable...
Transcriptome Research & Industry News, 2019-02-20 21:59:37

RNA-Seq reveals how the ‘Iron Man’ of immune cells helps T cells fight infection
The immune system’s killer T cells are crucial in fighting viral infections. A fraction of them, called ‘memory cells’, live on once infection is controlled...
Transcriptome Research & Industry News, 2019-02-20 21:47:25

Clinerion and Citeline team to streamline and improve decisionmaking for trials
Swiss clinical trial recruitment specialist Clinerion is partnering with Citeline as part of an effort to give clinical researchers a more comprehensive approach to making evidence-based decisions.
Fierce Biotech, 2019-02-20 21:15:25

Harnessing the microbiome potential
Spring is underway in parts of the US, and while Florida by no means undergoes the dramatic reappearance of foliage or colorful clumps of daffodils and azaleas, the southern part of the sunshine state experiences its share of spring renewals.  For instance, recently a brood of Muscovy duck (Cairina moschata) hatchlings appeared near Ocean Ridge Biosciences' laboratory.
ORB Company Blog, 2017-03-31 21:41:45

Nitisinone increases melanin in people with albinism
NIH clinical study results suggest the drug could help protect skin and prevent vision problems
National Institutes of Health, 2019-02-20 21:00:00

Pfizer CNS spinout Cerevel brings on new CMO to launch phase 3 work in Parkinson’s disease
Pfizer’s neuroscience spinoff, Cerevel Therapeutics, is bringing on Otsuka’s Raymond Sanchez, M.D., to serve as its new chief medical officer and take forward development of its late-stage programs for Parkinson’s disease and epilepsy into phase 3.
Fierce Biotech, 2019-02-20 19:45:32

ORB Employees Participate in 2019 Martin Luther King Day Event
ORB employees get a rare break from the lab on January 21, 2019. A group of Ocean Ridge Biosciences employees stepped out of the lab on a beautiful South Florida winter day to take part in an event honoring Martin Luther King. We got our hands dirty planting some flowers and shrubs at a local park in Deerfield Beach.
ORB Company News, 2019-01-22 23:24:59

Allogene Therapeutics to build out facility for allogeneic CAR T treatments
Another CAR T production facility is slated for the U.S. as a biotech moves down the road with a bucket full of cash and a fistful of candidates. But unlike currently approved CAR T treatments,  Allogene Therapeutics is looking to use donated T-cells that may simplify the very complex manufacturing processes.
Fierce Pharma, 2019-02-20 19:41:48